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       Prof Jonathan Brostoff, Dr Michael Radcliffe, Dr Harsha Kariyawasam, Dr Diana Church, Prof Martin Church
 

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Hay fever

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Causes

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Oral allergy syndrome

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Hay fever treatment

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The pollen count

Hay fever is caused by an allergic reaction to the pollen from grasses, plants and trees and in some cases fungal spores. A person suffering from hay fever may be allergic to anything from one to very many types of pollen.  Symptoms include sneezing, runny itching eyes and nose, sore throat, headache and tiredness.  

In the UK, grass pollen is the commonest cause of hay fever but also important are pollens from trees such as alder, hazel, birch and plane, and from weeds such as nettles and from garden plants. Some people suffer symptoms similar to hay fever all the year round due to dust mite allergy or pet allergy and this condition is known as perennial allergic rhinitis. perennial allergic rhinitis.

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Causes of hay fever

If you suffer from allergic symptoms, you can only know for certain if you have an allergy if you have it confirmed by an allergy assessment.  This includes enquiring about symptoms, history of allergy, exposure, family history etc., to get a good picture of your situation and to see what can be done to help

When hay fever is caused by allergy to pollen grains, skin prick testing is usually helpful. These tests involve a gentle prick through a drop of allergen extract on the surface of your arm (pictured left). This may result in a small swelling and a reddening of the skin, suggesting that you have an allergy.

An allergy blood test that looks for specific allergy antibodies (IgE antibodies) is often recommended to confirm the test result. If specific antibodies towards one or more allergens are found in the blood, it means that you are sensitised and are liable, either now or at some time in the future, to have an allergic reaction when exposed to these substances.

In the UK, hay fever is mainly caused by grass pollen allergy, but tree pollens also cause symptoms for some patients. Certain weeds, garden flowers and flowering shrubs can also cause symptoms in some patients.  Occasional patients are allergic to a wide range of pollens, and such patients can have symptoms due to pollens from late January until early October.

Symptoms indistinguishable from pollen allergy can also be caused by the spores from moulds and fungi.

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Oral allergy syndrome

Some hay fever sufferers experience an allergy of the mouth and throat called oral allergy syndromeIn most cases symptoms occur throughout the year, although for some the symptoms only occur during the pollen season.  In the UK, it is commonest amongst patients who turn out to be allergic to the pollen of the birch tree, although some grass pollen sensitive patients are also affected.  In the most common form, sufferers experience a localised swelling or itching of the lips, mouth, tongue or throat immediately after contact with certain fruits or vegetables that turn out to contain similar allergens to those present in the pollen to which they are also sensitive.  Reactions usually follow contact with the fresh fruit or raw vegetable (sometimes even handling them), although reactions to cooked foods can sometimes also occur.

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Hay fever treatment

There are three main ways of reducing the symptoms of hay fever.  These are avoidance, drug treatments and desensitisation.

Drug treatments
A wide variety of treatments is available.  Different patients have different patterns of symptoms and may therefore not all may be helped by the same treatments.  Depending on the patient and depending on the situation, there are a number of suitable drug treatments and information about the following treatments is provided:

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Nasal steroid sprays

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Steroid injections

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Antihistamines

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Steroid tablets

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Desensitisation treatment

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Other treatments

School children with hay fever suffer at examination timeUnfortunately, it is just when grass pollen counts tend to be at their highest in the UK that school, college and university students face their main examinations. Many people feel generally ill with hay fever, and their performance at examinations is impaired by the allergic reaction and often also by the antihistamines they take. 

June is also a popular month for weddings and outdoor events, and severe hay fever sufferers run the risk that their hay fever could seriously upset a happy day.

Faced with this problem, many simply put up with it, whilst others depend on antihistamine tablets, steroid nasal sprays, or herbal remedies from the chemist. They may assume that their GP can offer them no treatment that is any more effective. This is not correct, as a great deal can be done.

Nasal Steroid sprays
Steroid nasal sprays are most effective, but only if the treatment is commenced about week before the sufferer knows from previous experience that the hay fever is due. The spray is then used regularly every day whether there are symptoms or not, supplemented with antihistamine tablets if necessary, until the season is over. This regime makes sense because if the hay fever is allowed to develop the nose gets blocked, so nasal sprays become useless because the spray cannot get inside the nose. 

Antihistamines
It is important that the antihistamine chosen is one of the 'new generation' type, some of which are only available on prescription. The older type such, as chlorpheniramine (Piriton®), are still available under different brand names although they may be less effective than those available on prescription, and they may cause unacceptable drowsiness.

Steroid Injections
Depot steroid injections. have been given for many years for hay fever, and are very effective, but there are serious objections to this treatment. Quite a large dose of steroid is contained in the depot, and the drug is released into the circulation at a steadily decreasing rate over about six weeks. The amount released bears no relation whatever to the pollen count which varies dramatically from day to day and hour to hour. Steroid tablets (see below) are just as effective, and the dose can be more precisely matched to the symptoms.  

If the depot injection is given too soon it may all have been absorbed before the end of the season, symptoms recur, and another injection may be required. Most importantly, this treatment is have been found very occasionally to cause necrosis of the head of the femur, requiring hip replacement. Although this is a rare complication, it is clearly not reasonable to run even this risk for controlling hay fever. Also the injection sometimes causes a small dimple due to absorption of fat.

Steroid Tablets
In severe cases of hay fever that does not respond well to the standard treatments, a few oral steroid tablets can be prescribed to be taken for a few days when the hay fever is at its worst, or if there is an important occasion such as an important examination, a wedding, or a job interview. This treatment is 100% effective, and because it is taken for a short time only there is no significant risk of any side-effect because the total dose is much less than that given in a depot injection.

Desensitisation
An important reason to identify which pollens are responsible for the symptoms is the recent development of newer forms of desensitisation treatment. Such treatment can be considered when symptoms are severe, and when the standard treatment fail to provide reasonable relief.

This type of treatment for allergy and hay fever has always been far more widely used in other countries than in the UK.  This form of treatment (pioneered in the UK nearly 100 years ago) became popular as an alternative to drugs, but unfortunately the original form of this treatment was not without risk.  So in 1985 the Committee on Safety of Medicines placed restrictions on its use, and it declined in popularity.  

Recently, very safe forms of allergy desensitisation treatment have been developed, and this treatment is becoming popular again.  Many successful clinical trials have been done, and these have involved two basic methods.  One form of this allergy treatment is known as subcutaneous immunotherapy and involves a course of injections that are given weekly in the early part of each year.  A more recently introduced form of this allergy vaccine treatment is called sublingual immunotherapy and requires the patient to place some of the allergy vaccine as drops under the tongue several times each week starting several weeks before the hay fever season begins.

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© Dr. Harry Morrow-Brown. All Rights Reserved.

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The pollen count

A pollen chart that shows the pollination times for the main UK allergy-provoking pollens is provided  These seasons may vary by up to three weeks depending on which part of the UK, and depending on the climatic conditions.  In recent years there has been a tendency for pollination to start earlier as a result of milder winters, and warm spring weather conditions. 

During the main pollen season, counts that give an estimated forecast of the airborne load for individual pollens (tree pollens until the end of May, the grass pollens until August) are collected by the National Pollens and Aerobiology Research Unit at the University of Worcester.

Pollen forecasts are then prepared by using the pollen count information, knowledge of local vegetation and weather patterns. The pollen forecasts can help hay fever sufferers to plan their activities and medication. The index of risk relates to the quantitative categories as follows:

 
UK pollen count forecast from the BBC Index Conditions
8-10 Very High Risk
6-7 High Risk
4-5 Medium Risk
1-3 Low Risk

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References:

Perennial rhinitis. 
Saleh, H.A. and Durham, S.R. (2007) British Medical Journal 335(7618), 502-507.
Patient and physician perspectives on the impact etc, 
Scadding, G.K. et al. (2000) Clin Otolaryngol & Allied Sci 25(6), 551-557. [Abstract]
BSACI guidelines for the management of allergic and non-allergic rhinitis.
Scadding, G.K. et al. (2008)  Clin Exper Allergy 38(1), 19-42. [Abstract]
Prevalence and rate of diagnosis of allergic rhinitis in Europe. 
Bauchau, V. and Durham, S.R. (2004) Eur Resp J. 24;758-764. [Abstract] [Free Full-text]

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Recommended reading

Hay Fever - The Complete Guide - Brostoff and Gamlin

Hayfever: The Complete Guide
Prof Jonathan Brostoff and Linda Gamlin
Bloomsbury; ISBN: 0747516995

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ALLERGY
CLINICS

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Page last updated 20/05/2010