Component Allergy Testing

Component Allergy Testing

Measuring IgE levels to specific allergenic components provides a more accurate and detailed understanding of one’s sensitization pattern.

Allergens like pollen species, mites, or foods consist of various potential allergenic molecules that can trigger sensitization. By testing IgE levels to these components, healthcare providers gain valuable insights for managing individuals with allergen sensitivities. For instance, it can help determine the likelihood of severe symptoms.

Component testing serves a broad range of purposes, from diagnosing and managing allergic conditions to identifying patients who are suitable candidates for targeted immunotherapy. Component-Resolved Diagnostics (CRD) use has become a significant and likely indispensable aspect of allergy diagnostics.

Types of CRD

Alpha Gal Components (related to red meat):

• Code: ZZ37
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Alternaria Components:

• Profile Contents: M6 Alternaria alternate, m229 rAlt a 1
• Code: ZZ1
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Apple Components:

• Profile Contents: F49 Apple, f434 rMal d 1 (PR-10, Apple), f435 rMal d 3 (LTP, Apple)
• Code: ZZ36
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Aspergillus Components:

• Profile Contents: M3 Aspergillus fumigatus, m218 rAsp f 1, m219 rAsp f 2, m220 rAsp f 3, m221 rAsp f 4, m222 rAsp f 6
• Code: ZZ2
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Birch Components:

• Profile Contents: T3 Common silver birch, t215 rBet v 1 (PR-10 Birch), t216 rBet v 2 (Profilin, Birch), t220 rBet v 4 (Birch), t225 rBet v 6 (Birch), t221 rBet v 2, rBet v 4 (Birch)

• Code: ZZ3
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Brazil Components:

• Profile Contents: F18 Brazil nut, f354 rBer e 1 (Brazil nut)

• Code: ZZ4
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Cashew Components:

• Profile Contents: F202 Cashew nut, f443 rAna o 3 (Cashew nut)

• Code: ZZ35
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Cat Components:

• Profile Contents: E1 Cat dander, e94 rFel d 1 (Cat), e220 nFel d 2 (Cat serum albumin), e228 nFel d 4 (Cat), e231 nFel d 7 (Cat)

• Code: ZZ5
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Celery Components:

• Profile Contents: F85 Celery, f417 rApi g 1.01 (PR-10)

• Code: ZZ6
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Cow’s Milk Components:

• Profile Contents: F2 Milk, f76 nBos d 4 (alpha-lactalbumin, Milk), f77 nBos d 5 (beta-lactoglobulin, Milk), e204 nBos d 6 (BSA, Cow), f78 nBos d 8 (Casein, Milk)

• Code: ZZ7
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Dog Components:

• Profile Contents: E5 Dog dander, e101 rCan f 1 (Dog), e102 rCan f 2 (Dog), e221 nCan f 3 (Dog serum albumin), e229 rCan f 4 (Dog), e226 rCan f 5 (Dog), e230 rCan f 6 (Dog)

• Code: ZZ8
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Egg Components:

• Profile Contents: F1 Egg white, f75 Egg yolk, f233 nGal d 1 (Ovomucoid, Egg), f232 nGal d 2 (Ovalbumin, Egg), f323 nGal d 3 (Conalbumin, Egg), k208 nGal d 4 (Lysozyme, Egg)

• Code: ZZ9
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Fish Components:

• Profile Contents: F3 Cod, f355 rCyp c 1 (Carp), f426 rGad c 1 (Cod)

• Code: ZZ10
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Furry Animal Components:

• Profile Contents: E101 rCan f 1 (Dog), e102 rCan f 2 (Dog), e221 nCan f 3 (Dog serum albumin), e229 rCan f 4 (Dog), e226 rCan f 5 (Dog), e230 rCan f 6 (Dog), e94 rFel d 1 (Cat), e220 rFel d 2 (Cat serum albumin), e228 rFel d 4 (Cat), e231 rFel d 7 (Cat), e227 rEqu c 1 (Horse)

• Code: ZZ38
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Glycan Determinants:

• Profile Contents: K202 nAna c 2 (Bromelain, Pineapple)
• Code: ZZ27
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Hazel Nut Components:

• Profile Contents: F17 Hazel nut, f428 rCor a 1 (PR-10, Hazel nut), f425 rCor a 8 (LTP, Hazel nut), f440 nCor a 9 (Hazel nut), f439 rCor a 14 (Hazel nut)

• Code: ZZ11
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

House Dust Mite Components:

• Profile Contents: D1 Dermatophagoides pteronyssinus, d202 nDer p 1 (House dust mite), d203 nDer p 2 (House dust mite), d205 rDer p 10 (Tropomyosin, House dust mite), d209 rDer p 23 (House dust mite)

• Code: ZZ12
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Kiwi Components:

• Profile Contents: f84 Kiwi, f430 rAct d 8 (PR-10, Kiwi)

• Code: ZZ32
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Latex Components:

• Profile Contents: K82 Latex, k215 rHev b 1 (Latex), k217 rHev b 3 (Latex), k218 rHev b 5 (Latex), k220 rHev b 6.02 (Latex), k221 rHev b 8 (Profilin, Latex), k224 rHev b 11 (Latex)

• Code: ZZ13
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Lipid Transfer Proteins:

• Profile Contents: F420 rPru p 3 (LTP, Peach), f425 rCor a 8 (LTP, Hazel nut), f427 rAra h 9 (LTP, Peanut), w211 rPar j 2 (LTP, Wall pellitory), w233 nArt v 3 (LTP, Mugwort), f435 rMal d 3 (LTP, Apple), f433 rTri a 14 (LTP, Wheat), f442 rJug r 3 (Walnut)

• Code: ZZ23
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Lipocalins:

• Profile Contents: e101 rCan f 1 (Dog), e102 rCan f 2 (Dog)

• Code: ZZ28
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Olive Components:

• Profile Contents: T9 Olive, t224 nOle e 1 (Olive), t227 nOle e 7 (LTP, Olive), t240 rOle e 9 (Olive)

• Code: ZZ14
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Parvalbumins:

• Profile Contents: f355 rCyp c 1 (Carp), f426 rGad c 1 (Cod)

• Code: ZZ29
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Peach Components:

• Profile Contents: F95 Peach, f419 rPru p 1 (PR-10, Peach), f420 rPru p 3 (LTP, Peach), f421 rPru p 4 (Profilin, Peach)

• Code: ZZ15
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Peanut Components:

• Profile Contents: F13 Peanut, f422 rAra h 1 (Peanut), f423 rAra h 2 (Peanut), f424 rAra h 3 (Peanut), f447 rAra h 6 (Peanut), f352 rAra h 8 (PR-10, Peanut), f427 rAra h 9 (LTP, Peanut)

• Code: ZZ16
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Polcalcins:

• Profile Contents: t220 rBet v 4 (Birch), g210 rPhl p 7 (Timothy)

• Code: ZZ25
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

PR-10 Proteins:

• Profile Contents: T215 rBet v 1 (PR-10, Birch), f428 rCor a 1 (PR-10, Hazel nut), f419 rPru p 1 (PR-10, Peach), f353 rGly m 4 (PR-10, Soy), f352 rAra h 8 (PR-10, Peanut), f417 rApi g 1.01 (PR-10, Celery), f430 rAct d 8 (PR-10, Kiwi), f434 rMal d 1 (PR-10, Apple)

• Code: ZZ22
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Profilins:

• Profile Contents: t216 rBet v 2 (Profilin, Birch), f421 rPru p 4 (Profilin, Peach), g212 rPhl p 12 (Profilin, Timothy), k221 rHev b 8 (Profilin, Latex)

• Code: ZZ24
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Seed Storage Proteins:

• Profile Contents: F423 rAra h 2 (Peanut), f354 rBer e 1 (Brazil nut), f431 nGly m 5 (beta-conglycinin Soy), f432 nGly m 6 (Glycinin), f422 rAra h 1 (Peanut), f424 rAra h 3 (Peanut), f440 nCor a 9 (Hazel nut), f439 rCor a 14 (Hazel nut), f416 rTri a 19 (Omega-5 Gliadin, Wheat), f443 rAna o 3 (Cashew nut)

• Code: ZZ26
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Serum Albumins:

• Profile Contents: e204 nBos d 6 (BSA, Cow), e220 nFel d 2 (Cat serum albumin), e221 nCan f 3 (Dog serum albumin), e222 nSus s (Pig serum albumin, Swine)

• Code: ZZ30
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Shrimp Components:

• Profile Contents: F24 Shrimp, f351 rPen a 1 (Tropomyosin, Shrimp)

• Code: ZZ17
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Soybean Components:

• Profile Contents: F14 Soybean, f353 rGly m 4 (PR-10, Soy), f431 nGly m 5 (beta-conglycinin, Soy), f432 nGly m 6 (Glycinin)

• Code: ZZ18
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Timothy Grass Components:

• Profile Contents: G6 Timothy grass, g205 rPhl p 1 (Timothy), g206 rPhl p 2 (Timothy), g208 nPhl p 4 (Timothy), g215 rPhl p 5b (Timothy), g209 rPhl p 6 (Timothy), g210 rPhl p 7 (Timothy), g211 rPhl p 11 (Timothy), g212 rPhl p 12 (Profilin, Timothy), g213 rPhl p 1/rPhl p 5b (Timothy), g214 rPhl p 7/rPhl p 12 (Timothy)

• Code: ZZ19
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Tropomyosins:

• Profile Contents: f351 rPen a 1 (Tropomyosin, Shrimp), d205 rDer p 10 (Tropomyosin, House dust mite)

• Code: ZZ31
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Venom Components:

• Profile Contents: I208 rApi m 1 (Phospholipase A2, Honey bee), i214 rApi m 2 (Hyaluronidase, Honey bee), i215 rApi m 3 (Acid phosphatase, Honey bee), i216 rApi m 5 (Dipeptidyl peptidase, Honey bee), i217 rApi m 10 (Icarapin, Honey bee), i211 rVes V 1 (Phospholipase A1, Common wasp), i209 rVes V 5 (Common wasp), i210 rPol d 5 (Paper wasp)

• Code: ZZ33
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Wall Pellitory Components:

• Profile Contents: W21 Wall pellitory, w211 rPar j 2 (LTP, Wall pellitory)

• Code: ZZ20
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Walnut Components:

• Profile Contents: F256 Walnut, f441 rJug r 1 (Walnut), f442 rJug r 3 (LTP, Walnut)

• Code: ZZ34
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None

Wheat Components:

• Profile Contents: F4 Wheat, f98 Gliadin, f433 rTri a 14 (LTP, Wheat), f416 rTri a 19 (Omega-5 Gliadin, Wheat)

• Code: ZZ21
• Sample Requirements: B
• Turnaround Time: 2 days
• Special Instructions: None